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ILAR J. Mannan, A. A type of emphysema a lung problem is caused by the ER quality control section continually rejecting an incorrectly folded protein.
The protein is wrongly folded as a result of receiving an altered genetic message. The required protein is never exported from the lumen of rough ER. Rigorous quality control plays a part in cystic fibrosis A form of cystic fibrosis is caused by a missing single amino acid, phenylanaline, in a particular position in the protein construction.
The protein might work well without the amino acid but the very exacting service provided by the quality control section spots the error and rejects the protein retaining it in the lumen of the rough ER. In this case the customer the person with cystic fibrosis loses out completely due to high standards when a slightly poorer product would have been better than no product at all.
They are conveyed in vesicles or possibly directly between the ER and Golgi surfaces. It is found fairly evenly distributed throughout the cytoplasm. Smooth ER is devoted almost exclusively to the manufacture of lipids and in some cases to the metabolism of them and associated products. In liver cells for example smooth ER enables glycogen that is stored as granules on the external surface of smooth ER to be broken down to glucose.
Smooth ER is also involved in the production of steroid hormones in the adrenal cortex and endocrine glands. Smooth ER — the detox stop Smooth ER also plays a large part in detoxifying a number of organic chemicals converting them to safer water-soluble products. So the endoplasmic reticulum is an organelle that's really a workhorse in producing proteins and substances needed by the rest of the cell. Endoplasmic Reticulum Rough.
William Gahl, M.
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